One review found low-quality evidence that low-dose colchicine (1.8 mg in one hour or 1.2 mg per day) reduced gout symptoms and pain, whereas high-dose colchicine (4.8 mg over 6 hours) was effective against pain, but caused more severe side effects, such as diarrhea, nausea or vomiting. There is preliminary evidence that daily colchicine (0.6 mg twice daily) was effective as a long-term prophylaxis when used with allopurinol to reduce the risk of increased uric acid levels and acute gout flares, In gout, inflammation in joints results from the precipitation of circulating uric acid, exceeding its solubility in blood and depositing as crystals of monosodium urate in and around synovial fluid and soft tissues of joints. About 10-20 percent of a colchicine dose is excreted unchanged by the kidneys; it is not removed by hemodialysis. Cumulative toxicity is a high probability in this clinical setting, and a severe neuromyopathy may result. The presentation includes a progressive onset of proximal weakness, elevated creatine kinase, and sensorimotor polyneuropathy. Colchicine toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs. According to one review, colchicine poisoning by overdose (range of acute doses of 7 to 26 mg) occurs in three phases: 1) a gastrointestinal phase occurring 10–24 hours after ingestion; 2) a phase having poor prognosis involving multiple organ dysfunction occurring 24 hours to 7 days after ingestion, potentially evolving into rapid, progressive multi-organ failure and sepsis; 3) several weeks would be needed for a complete recovery if there are no complications. Historic, Archive Document Do not assume content reflects current scientific knowledge, policies, or practices c P^ C H ARS 34-24 S EA ^g~**m «W SERIAL RECORDS THE USE OF COLCHICINE IN PLANT BREEDING August 1961 U S Agricultural DEPARTMENT Research Service OF AGRICULTURE ARS- 34-24 August 19 bl THE USE OF COLCHICINE IN PLANT BREEDING By Haig Dermen and S. Emsweller— ' Colchicine, a poisonous medicinal chemical, has been used since 1937 in plant breeding work to produce changes in plants by doubling the number of chromosomes in cells, a condition referred to as polyploidy. 6811 Please reverse slip in returning the publication. The increased number of chromosomes usually brings about an increase in size of the affected cells and various degrees of changes in their functions. REFERENCE BEGINS ON PAGE autpxinu tunos 2S0T LP-615 (Rev. In contrast with the normal plants, those developed by colchicine treatment often show changes in height and width; in thickness of branches; in size, shape, and texture of leaves, flowers, fruits, and seeds; in fertility of flowers; and in physiological responses, However, the degree of changes produced when the chromosome number is doubled cannot be predicted, and "magic" changes referred to by some popular writers are not to be expected. The visual changes induced in some plants are so small that even an experienced person will have difficulty in recognizing them. Colchicine is extracted from either the seeds or the corms of Colchicum autummale L. (meadow saffron or fall crocus) and may be bought in very small quantities in powder form from certain chemical concerns mentioned at the end of this article. A small quantity of colchicine can be used to treat a large number of plants, seeds, or other types of material, if applied without undue waste.
Colchicine is a medication most commonly used to treat gout. In addition to gout, colchicine is. The plant source of colchicine, the autumn crocus Colchicum autumnale, was described for treatment of. both in oral and intravenous forms, but gave pharmacies the opportunity to buy up the older unapproved colchicine. Chromosome doubling in plant species. Diploid cotton species. it less preferable. Colchicine treated plants are. higher order polyploids. G. arboreum and G.