The FDA recently released a Drug Safety Communication announcing revisions to metformin’s label to expand use in people with type 2 diabetes and mild to moderate kidney (renal) impairment. Previously, the FDA advised against using metformin (Glucophage, Glumetza, Riomet, and Fortamet) in this group. The news could bring metformin to as many as 1.6 million more people with diabetes – a major win for the most widely prescribed diabetes drug. Metformin – a safe, cheap, and effective first-line drug in type 2 diabetes – was approved back in 1994. At the time, the FDA had concerns that metformin (which is cleared from the body through the kidneys) would accumulate in the bloodstream of people with reduced kidney function and put them at risk for lactic acidosis – a serious life-threatening condition if left untreated. As a result, the FDA prohibited metformin use for people with moderate to mild kidney disease. Physicians could still prescribe the drug “off-label,” though the safety warning certainly prevented many from accessing the drug. Metformin is a drug commonly used in the treatment of Type 2 diabetes. Which of the following are potential side effects of metformin? Your doctor will closely monitor your liver with blood tests if you are taking metformin and have a history of liver disease. Your doctor may advise you to stop taking metformin for two days before and two days after such an x-ray to avoid problems. It is sold as a generic and under several brand names, including Glucophage, Glumetza, Riomet, and Fortamet. Major surgery can lead to reduced fluids in the blood and sometimes reduced kidney function, raising the risk of lactic acidosis. Like any drug, metformin can interact with certain other drugs. Both the American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists (AACE) recommend metformin as a cornerstone of therapy for Type 2 diabetes when exercise and dietary changes aren’t enough to keep blood glucose levels in target range. Reduced retinopathy (damage to the retina, a membrane in the eye). Before you start any new drugs, therefore, ask your doctor about potential interactions and what the symptoms of such interactions might be. The low cost of the generic forms along with a long history of use make it a good choice for many individuals with Type 2 diabetes. Your pharmacist is another good source of information on drug interactions and side effects. Although metformin has helped many people lower their blood glucose levels, it does have some potential side effects that are worth knowing about. It’s always a good idea to check in with your doctor before starting an exercise program or intensifying your workouts. Understanding the risks and benefits of metformin is key to using it successfully. But taking metformin should not hinder or interfere with your ability to exercise. Take this quiz to test your knowledge of this popular diabetes medicine. It decreases the amount of glucose produced by the liver and makes it easier for cells to accept glucose from the bloodstream. It slows the digestive system’s breakdown of carbohydrates into glucose, allowing more time for insulin to work. It suppresses appetite, slows stomach emptying, and inhibits the release of glucagon (a hormone that raises blood glucose levels). In addition to lowering blood glucose, metformin sometimes causes moderate weight loss. In research studies, metformin use was associated with which of the following benefits in people with Type 2 diabetes?
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. If you have Polycystic Ovary Syndrome (PCOS) and have been prescribed metformin, chances are you have a lot of questions and concerns about taking this medication. The majority of women with PCOS have high insulin levels which cause weight gain, cravings, and even dark patches on your skin. Over time, exposure to high insulin levels can make you insulin resistant or turn into type 2 diabetes. Metformin works to lower your insulin and reduce your risk for diabetes. Metformin is one of the oldest and most studied drugs available in the United States. Other names for metformin include Glucophage, Glucophage XR, glumetza, and fortamet. Although it’s not labeled for use in women with PCOS, metformin is one of the most common medications used to manage the condition.
Nov 27, 2017. Losing weight is one of the most common metformin side effects. If you're managing type 2 diabetes with metformin Glucophage, you might be. Eating Eggs Doesn't Raise the Risk of Type 2 Diabetes, Study Suggests. Aug 16, 2017. I admit it I took metformin for a week, the leading prescribed drug for treatment. After all, I don't take any other drugs so I had no real risk of the.