Three groups of hypertensive patients were studied after they had received one of the three pharmacologically different beta blockers for at least 1 month: pindolol, 10 mg twice a day (n = 7), propranolol median dose, 80 mg three times a day (n = 9), or metoprolol, 150 mg (twice a day (n = 8). After abrupt withdrawal of drug and replacement with placebo, we mwasured the following on day 0 and approximately every 2 days up to 3 weeks; beta-adrenergic sensitivity (BAS) by the chronotropic dose of isoproterenol to increase heart rate by 25 bpm (CD values of 618 μg for pindolol, 57 μg for propranolol, and 10 μg for metoprolol as compared to 2.8, 2.4, and 3.0 μg, respectively, at days 14 to 21, which were considered the ultimate baseline. After pindolol on day 0, the CD decreased significantly two- to fivefold below baseline from days 4 to 14 (↑BAS) and after metoprolol two- to threefold below baseline from days 2 to 8. After pindolol, heart rate and blood pressure gradually returned to, but not above, ultimate baseline. In contrast, during the period of ↑BAS there was a significant overshoot of heart rate in eight of eight patients after metoprolol (day 0 = 61, peak = 88, baseline = 74) but not after propranolol, while a significant overshoot of blood pressure occurred in six of nine patients after propranolol () but not after metoprolol. Withdrawal symptoms of headache, palpitations, and tremor occurred in one of seven patients after pindolol, six of nine after propranolol, and three of eight after metoprolol. The degree and duration of beta blockade appeared related to drug potency. Last week with the support of my Dr I came off metoprolol over three days. 24 hours after my last half pill my resting heart rate was up from my normal 60/65 to 90/100 but after a week was back to almost normal. The first night was pretty bad with almost no sleep but for the rest of the week I just felt a bit of however I have gone back on metoprolol today because my blood pressure which has been pretty good for a long time at 120/130 over 65/75 topped out at 174/86 and has regularly been over 160 over the last week. Has anyone out there had withdrawal symptoms from beta-blockers and if so how long did it take to settle down. It is not a problem for me being on beta-blockers as they don't seem to have many side-effects apart from the odd nightmare, I don't know whether I should have just stuck it out and hopefully come right but high blood pressure really does make me nervous.
Can Metoprolol cause Withdrawal Symptoms? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. About 6 months ago I had a brief spell of a-fib that caused a chain reaction of doctor visits, cariologist visits, tests that all came out normal. My cardiolog.