Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. JAMAJAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Pollack MHSmoller JW Pharmacologic approaches to treatment-resistant panic disorder. Pollack MHOtto MWRosenbaum JFeds Challenges in Clinical Practice Pharmacologic and Psychosocial Strategies New York, NY Guilford Press1996;89- 112Google Scholar Oehrberg SChristiansen PEBehnke KBorup ALSeverin BSoegaard JCalberg HJudge ROhrstrom JKManniche PM Paroxetine in the treatment of panic disorder: a randomized, double-blind, placebo-controlled study. 1995;167374- 379Google Scholar Den Boer JAWestenberg JGM Effect of a serotonin and noradrenaline uptake inhibitor in panic disorder: a double-blind comparative study with fluvoxamine and maprotiline. 1988;359- 74Google Scholar Sharp DMPower KGSimpson RJSimpson VMoodie EAnstee JAAshford JJ Fluvoxamine, placebo and cognitive behavior therapy used alone and in combination in the treatment of panic disorder and agoraphobia. 1996;10219- 242Google Scholar Reimherr FWByerley WFWard MFLebegue BJWender PH Sertraline, a selective inhibitor of serotonin uptake, for the treatment of outpatients with major depressive disorder. 1988;24200- 205Google Scholar Greist JChouinard GDu Boff EHalaris AKim SWKoran LLiebowitz MLydiard RBRasmussen SWhite KSikes C Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder. 1995;52289- 295Google Scholar Clark DMSalkovskis PMHackmann AMiddleton HPavlos AGelder M A comparison of cognitive therapy, applied relaxation and imipramine in the treatment of panic disorder. 1994;164759- 769Google Scholar Tesar GERosenbaum JFPollack MHOtto MWSachs GSHerman JBCohen LSSpier SA Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder.
Sertraline is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD). Sertraline belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the activity of a chemical called serotonin in the brain. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Sertraline is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It's often used to treat depression, and also sometimes panic attacks, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). Sertraline helps many people recover from depression, and has fewer unwanted side effects than older antidepressants. Sertraline comes as tablets, which are available only on prescription. Sertraline can be taken by adults for depression or obsessive compulsive disorder. Sertraline can be taken by children aged 6 to 17, but only for obsessive compulsive disorder. Check with your doctor before starting to take sertraline if you: If you have diabetes, sertraline can make it more difficult to keep your blood sugar stable. You can choose to take sertraline at any time, as long as you stick to the same time every day.
ZOLOFT sertraline hydrochloride tablets, for oral use. ZOLOFT sertraline. Hepatic impairment o Mild Recommended starting and maximum dosage is half. Dose of ARROW - SERTRALINE is 25 mg per day, increasing to one 50 mg tablet a day after one week. The maximum recommended dose of ARROW.