Duloxetine cymbalta

Posted: VMar Date: 03-Feb-2019
<b>Cymbalta</b> <b>Duloxetine</b> - Side Effects, Dosage, Interactions - Drugs

Cymbalta Duloxetine - Side Effects, Dosage, Interactions - Drugs

It is a prescription-only drug approved for the treatment of chronic musculoskeletal pain and chronic low back pain, which can be caused by conditions such as osteoarthritis. Subsequently, it was also approved for treatment of anxiety, pain caused by diabetic neuropathy, and pain caused by fibromyalgia before gaining FDA approval for chronic musculoskeletal pain in 2010. Food and Drug Administration (FDA) in 2004 for major depressive disorder. Cymbalta increases the action of serotonin and norepinephrine, which are natural neurotransmitters produced by the body. This effect of Cymbalta alleviates depression and anxiety and decrease pain signals in the brain, spinal cord, and nerves. It has also been suggested that Cymbalta could reduce inflammation or oxidative damage, but these theories have not been proven at this time. Prior to the approval of Cymbalta for musculoskeletal pain, several double-blind, placebo-controlled, randomized clinical trials confirmed that study participants taking Cymbalta had significantly greater pain reduction than participants taking a placebo. Since its approval, more recent studies have shown that Cymbalta reduces chronic musculoskeletal pain and that it is well tolerated. Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain. This medicine is available only with your doctor's prescription.

<b>Duloxetine</b> <b>Cymbalta</b> Side Effects, Dosages, Treatment, Interactions.

Duloxetine Cymbalta Side Effects, Dosages, Treatment, Interactions.

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Show More Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Der Serotonin- und Noradrenalin-Wiederaufnahmehemmer Duloxetin, der als YENTREVE seit August 2004 zur Therapie der Belastungsinkontinenz angeboten wird (a-t 2004; 35: 120), ist jetzt als CYMBALTA zur Behandlung von Depressionen im Handel.1 CYMBALTA wird zu einer Zeit eingeführt, in der Nutzen und Sicherheit insbesondere der neueren Antidepressiva zunehmend in die Diskussion geraten (a-t 2003; 34: 63-4 und 114; 2004; 35: 45-; 36: 1-2; siehe Seite 45). EIGENSCHAFTEN: Ähnlich wie Venlafaxin (TREVILOR) hemmt Duloxetin die Wiederaufnahme von Serotonin und Noradrenalin, schwächer auch von Dopamin.1,2 Die Pharmakokinetik von Duloxetin unterliegt einer großen Variabilität. Die orale Bioverfügbarkeit beträgt zwischen 30% und 80%. Duloxetin wird in der Leber durch die Zytochrom-P(CYP)-450-Enzyme 2D6 und 1A2 verstoffwechselt. Die Eliminationshalbwertszeit liegt zwischen 8 und 17 Stunden. Duloxetin darf nicht bei Leberfunktionsstörungen, schwerer Niereninsuffizienz und nicht zusammen mit starken CYP-1A2-Hemmern wie Ciprofloxacin (CIPROBAY u.a.) eingenommen werden.1 KLINISCHE WIRKSAMKEIT: Wie andere neuere Antidepressiva3 wirkt auch Duloxetin kaum besser als ein Scheinmedikament (vgl. Von den sechs Phase-3-Studien zur Akuttherapie der Depression mit insgesamt knapp 2.000 Patienten, die der europäischen Zulassung zugrunde liegen, sind zwei negativ.2 Vollständig veröffentlicht sind, wie zu erwarten, nur die vier Positivstudien (vgl. a-t 2004; 35: 29-30 und 45-6).4-7 Der Plazeboeffekt reicht von 54% bis 92% des Verumeffekts, gemessen nach acht bis neun Wochen anhand der HAMILTON-Depressionsskala*.

Duloxetin Wirkung, Anwendungsgebiete, Nebenwirkungen.
Duloxetin Wirkung, Anwendungsgebiete, Nebenwirkungen.

Jan. 2017. Duloxetin ist ein Wirkstoff, der zur Behandlung verschiedener psychischer Erkrankung und Nervenleiden eingesetzt wird. Lesen Sie hier mehr. Jan 18, 2018. Get information on the drug Cymbalta duloxetine for fibromyalgia, including how it works, what research shows, a typical dosage, and side.

Duloxetine cymbalta
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