Board-certified physicians medically review Drugwatch content to ensure its accuracy and quality. Drugwatch partners with Physicians’ Review Network Inc. PRN is a nationally recognized leader in providing independent medical reviews. Reviewer specialties include internal medicine, gastroenterology, oncology, orthopedic surgery and psychiatry. Zoloft (sertraline chloride) is one of the most popular SSRI antidepressants on the market. Pfizer developed and marketed Zoloft as a safer alternative with fewer side effects and withdrawal symptoms than competitor drugs such as Eli Lilly’s Prozac. Zoloft treats a wide variety of psychiatric disorders, but it may also cause birth defects, suicidal thoughts, autism and withdrawal symptoms. I was started on Zoloft 5 weeks ago at 50 mg and was doing great at week 4 - at that time Zoloft was increased to 75 mg and I have been taking that dose for 7 days and I feel agitated and anxious. I am not sure how long I should give the dose increase side effects to go away or just go back to taking 50 mg, I was doing very well on 50 mg. I called my mental health facility but there is not a nurse there today. The Pharmacist there had no answers and my appointment with the NP isn't until June the 18th. I know it takes 6 to 8 weeks to really get into your system and I expected side effects when I first started Zoloft but am not sure about these side effects after 7 days going from 50 to 75 mg - Agitation, anxiety, skin burning from the inside out, etc. I am also taking 300 mg of gabapentin 3 times a day, vistaril, and klonopin. Overall, I have had an extremely positive experience with it. Any replies are appreciated, thanks =) Hi,my name is Kristie I was on Zoloft about 10 year's ago, was on it about a year I quit because of a few side effects the main one was no sex drive....almost lost my boyfriend because of it!!! Was off depression meds until 3 years ago when I got diagnostics with stage 4 breast cancer. Whenever the dosage was adjusted, I would notice some side effects.
It's also used to treat obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (PMDD) and social anxiety disorder. Zoloft, an oral antidepressant pill made of compressed crystalline powder, is usually prescribed to first-time users in a 50-milligram-per-day dose for depression and PMDD and 25 milligrams per day for other disorders. Our bodies need time to adapt to the new normal created by taking a pill laced with sertraline that is designed to increase serotonin levels in the brain. Dosages can be increased with time and medical supervision up to 200 milligrams per day. Not only does this SSRI medication help the brain absorb serotonin into the blood stream more effectively, but it may actually change the makeup of the brain. It's also available in liquid form [source: RX List]. The brain needs new receptors to help absorb the additional serotonin; it builds and installs additional receptors -- a biological process that can take up to eight weeks. Within just a few hours of taking an SSRI for the first time, the levels of serotonin in the brain and bloodstream increase. So, even though Zoloft increases the levels of serotonin in our bodies nearly immediately, our brains aren't immediately equipped to absorb it [source: Crowe]. If, however, after six to eight weeks, Zoloft doesn't seem to be positively affecting your mood, anxiety -- or other condition for which it was prescribed -- it's time to alert your physician. Not every antidepressant will work the same for every person, and an estimated 50 percent of people who try an antidepressant will need to take a different brand or class before finding one that works for them. Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
Sertraline treatment prevented increases in body weight, fat, insulin, and. Both metabolic syndrome and depression increase CVD risk. Brand and Other NamesZoloft. May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg qDay when administered continuously.