If you need urgent medical help, call triple zero immediately healthdirect Australia is a free service where you can talk to a nurse or doctor who can help you know what to do. Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, which is converted to aciclovir in a persons body. Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism.
The dose in immunocompromised patients is 1000 mg three times daily for at least seven days (3000 mg total daily dose) and for 2 days following crusting of lesions. This dose should be reduced according to creatinine clearance (see Renal impairment below). For recurrent episodes, treatment should be for three to five days. For initial episodes, which can be more severe, treatment may have to be extended to ten days. For recurrent episodes of herpes simplex, this should ideally be during the prodromal period or immediately upon appearance of the first signs or symptoms. Valtrex can prevent lesion development when taken at the first signs and symptoms of an HSV recurrence. For herpes labialis (cold sores), valaciclovir 2000 mg twice daily for one day is effective treatment in adults and adolescents. The second dose should be taken about 12 h (no sooner than 6 h) after the first dose. 1 answer I got a cold sore last week and took the 2grams twice a day for one day. Then today I woke up (4 days later) and felt that tingling feeling again on my lips so I took 2 grams of Valtrex right away. Woke up Sunday morning, felt a tingle but wasn't sure so I let a few hours pass and... I've never noticed any warts or genital sores, & He "Claims" his dermatologist prescribed it for his face! And I Do know he's said he's had achne problems in the past. read more 3 answers I have been getting valacyclovir hcl 500mg which is a generic of valtrex, its a blue tablet with a v.5 on one side and the actavis imprint on the other. But what I noticed was that my whole top lip was basically covered... Like many of you I have suffered all my life with cold sores, some outbreaks worse then others. It has worked just fine, I just picked up my refill and it's a white tablet with m122. I've never taken this brand before nor have I... read more 3 answers I have had shingles for 8 weeks. I am using a cream compounded by local pharmacy, plus lidocaine , ibuprofen, gabapentin, and more. If you have had experience with shingles and know of any medication that helped you... read more 2 answers I've just been diagnosed with genital herpes and at 22 my life feels upside down especially because I've always been careful. I guess I am having a hard time coping and feel as if my life is over. My boyfriend has been very supportive but nothing is making me feel better. read more 1 answer My doctor prescribed Valtrex, but when I got the refill the pharmacy filled it with Acyclovir.
Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes. Elimination half-life, 30 minutes valaciclovir; 2.5–3.6 hours. Other names Valtrex®. WHY is this drug prescribed? Valacyclovir is an antiviral agent used to treat infections such as genital herpes. HSV and herpes zoster.