After all, your four-legged friend is a member of your family. We understand, our dogs are very much our family members as well. That's why when something is wrong with Fido, dog owners can often find themselves quickly spiraling into panic mode. Why do they have a laundry list of associated side effects? A timely trip to the veterinarian will often leave a pet owner feeling calmer in one sense, but potentially more concerned in other areas. Again, we understand what a worrisome time it can be. First, your beloved pup is ill, which is bad enough on its own. But then, you have to make the difficult choices as to what is the right answer in terms of medication. In this article, we are breaking down an extremely popular steroid drug called prednisone. The fine print may read that a drug that should simply ease the symptoms of allergies may also have long-term, irreversible side effects. We hope to answer all of your questions and concerns and help our readers become as educated as possible on the medication so that they can make the best decision possible in terms of their fur baby's health. Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Although there are no major human studies of prednisolone use in pregnant women, studies in several animals show that it may cause birth defects including increase cleft palate. Prednisolone should be used in pregnant women when benefits outweigh the risks and children born from mothers using prednisolone during pregnancy should be monitored for impaired adrenal function. Prednisolone is found in breast milk of mothers taking prednisolone. As a glucocorticoid, the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.
Over many years, prednisone and prednisolone given to both dogs and cats were believed to be absolutely the same regarding bioavailability, effect and tolerance. But is this really true? This question was raised by an American study group and evaluated carefully. The surprising result oral prednisolone is the superior choice for cats! Prednicare is indicated as an anti-inflammatory and anti-allergic agent for use in cats and dogs. Prednicare contains the active ingredient Prednisolone.