Some clinicians select amoxicillin over penicillin VK to treat odontogenic infection because of a more convenient dosing regimen e.g., 2-3 doses daily for amoxicillin versus 4 doses daily for penicillin VK. Except for coverage of Haemophilus influenzae in acute sinus and otitis media infections, amoxicillin is not any more effective than penicillin VK for the treatment of odontogenic infections. It is less effective than penicillin VK against aerobic gram-positive cocci and similar in efficacy against anaerobes. Thus penicillin VK is the drug of choice for treating odontogenic infections. Contraindications: Hypersensitivity to amoxicillin, penicillin or any component of the formulation. Warnings/Precautions: Use with caution in patients with severe renal impairment (modify dosage); low incidence of cross-allergy with other beta-lactams and cephalosporins exists. The usual daily oral dose for treating odontogenic infections in children is: Children under 12 years: 20-40 mg/kg divided in 2-3 doses daily for 10 days. Formulations of amoxicillin for oral suspension, USP contain amoxicillin, a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Chemically, it is (2 O, and the molecular weight is 419.45. Amoxicillin for oral suspension is intended for oral administration. Each 5 m L of reconstituted suspension contains amoxicillin trihydrate equivalent to 200 mg or 400 mg anhydrous amoxicillin. Each 5 m L of the 200 mg and 400 mg reconstituted suspension contains 0.16 m Eq (3.61 mg) of sodium. Amoxicillin trihydrate for oral suspension 200 mg/5 m L and 400 mg/5 m L (reconstituted) are bubble-gum flavored pink suspensions. Inactive ingredients: Sucrose, sodium citrate, sodium benzoate, edetate disodium, FD&C Red No.
Children over 12 years and adults 250-500 mg 3 times/day, maximum 2-3 gm/day for 10 days. Amoxicillin is supplied as a 125, 200, 250, 400 mg/5 ml solution. Table 3 Mean Pharmacokinetic Parameters of Amoxicillin 400 mg chewable tablets and 400 mg/5 mL suspension in Healthy Adults Administered at the start of a light meal. Mean values of 24 normal volunteers.